Exploring the behaviour of water nanodroplet on a coplanar electrowetting-on-dielectric: a molecular dynamics approach

Micro & nano letters

article

Hoi Kei Chan¹  Pui In Mak¹  Shirley W.I. Siu¹ 

[1] Department of Computer and Information Science, University of Macau, Avenida da Universidade;State-Key Laboratory of Analog and Mixed-Signal VLSI, Department of Electrical and Computer Engineering, University of Macau, Avenida da Universidade

关键词: water;    drops;    wetting;    molecular dynamics method;    hydrogen bonds;    contact angle;    water nanodroplet;    coplanar electrowetting-on-dielectric;    molecular dynamics simulation;    hydrophobic surface;    applied electric field;    open-plate coplanar electrodes system;    electrode-induced field;    contact angle;    hydrogen bonding;    diffusion coefficient;    water molecules;    hydration layer;    water diffusion;   

DOI  :  10.1049/mnl.2016.0824

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background: Palonosetron is a second generation 5-Hydroxytryptamine-3 receptor antagonist with longer half-life and higher receptor binding affinity than Ondansetron. Aims & objective: To assess the efficacy and safety profile of intravenous palonosetron cpompared to the ondansetron for prevention of post-operative nausea and vomiting (PONV) under general anesthesia. Methodology: A prospective, randomized, placebo-controlled, double-blind study was conducted in   90 patients aged 20-60 years, undergoing major surgeries. Group I (n=30) received placebo injection; Group II (n=30) received inj. ondansetron 8 mg and Group III (n=30) received inj. palonosetron 0.075 mg IV. In the operating room, the study drugs were given IV in equal volume of 4ml, before inducing the patients. In postoperative period each patient was observed for retching, nausea and/or vomiting at30 min; and then at 1, 2, 6, 12 and 24 hours. Any side effects intra-operatively and post-operatively were recorded. Results: The number of patients, who remained vomiting free in the first 24 hours after surgery was 56.6%, 80% and 86% in the placebo, Ondansetron and Palonosetron groups respectively. The difference with placebo was highly significant for ondansetron (p < 0.05), and highly significant for palonosetron (p=0.009). The difference in vomiting between Ondansetron and Palaonosetron was not significant but the incidence of nausea was significantly less common in the Palonosetron group than the Ondansetron group (16.7% vs. 43.4%, p=0.006). Conclusion: We conclude that the second generation 5-HT3 antagonist, palonosetron is significantly more effective against PONV than ondansetron. It has a particularly more pronounced and prolonged effect on postoperative nausea.

【 授权许可】

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