Investigation on the effects of variable shear stress on monocyte cell morphology

Micro & nano letters

article

Semra Zuhal Birol¹  Rana Fucucuoglu²  Sertac Cadirci³  Ayca Sayi-Yazgan²  Levent Trabzon¹ 

[1] Department of Nanoscience and Nanoengineering, Istanbul Technical University;Department of Molecular Biology and Genetics, Istanbul Technical University;Department of Mechanical Engineering, Istanbul Technical University

关键词: cellular biophysics;    haemodynamics;    microchannel flow;    biomechanics;    blood vessels;    fluorescence;    diseases;    variable shear stress effects;    monocyte cell morphology;    microchannels;    soft lithography;    mechanobiological applications;    cell culture platforms;    physiological shear stress levels;    veins;    arteries;    circular system;    microfluidic pump;    structural changes;    CFD;    THP-1 cells;    F-actin content;    phalloidin;    mean fluorescence intensity;    fluorescence microscopy;    flow cytometry;    THP-1 monocytic cell actin polymerisation;    shear stress conditions;    pathological condition;    atherosclerosis;   

DOI  :  10.1049/mnl.2017.0432

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Introduction: In this study we compared the use of an intravenous propofol/propofol auto-co-induction technique to propofol/midazolam for laryngeal mask insertion. We also studied the incidence of undesirable effects in relation to LMA insertion. Methodology: In this prospective, randomized, controlled trial study, 60 adults belonging to ASA class 1 and 2 were randomly divided in three groups; Group1- Saline-propofol; Group 2- Propofol-midazolam; Group 3- Propofol-propofol. The induction characteristics reviewing various parameters like the induction dose required, hemodynamic changes and the cost of induction were observed. Hemodynamic variables including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded at 2, 4 and 6 minutes post induction.

【 授权许可】

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