Preparation and characterisation of silver nanoparticles in an aqueous suspension of TETA modified graphene oxide and their antibacterial activity

Micro & nano letters

article

Ran Luo¹  Zhiyao Xu¹  Xuemei Lin¹ 

[1] Institute of Chemistry, Nanjing University of Science and Technology

关键词: silver;    nanoparticles;    particle reinforced composites;    suspensions;    organic compounds;    graphene;    nanocomposites;    antibacterial activity;    nanofabrication;    self-assembly;    Fourier transform infrared spectra;    ultraviolet spectra;    visible spectra;    X-ray diffraction;    X-ray photoelectron spectra;    scanning electron microscopy;    transmission electron microscopy;    nanomedicine;    microorganisms;    silver nanoparticles;    aqueous suspension;    TETA modified graphene oxide composite;    antibacterial activity;    triethylenetetramine-functionalised graphene oxide nanomaterial;    electrostatic self-assembly;    antimicrobial properties;    structural properties;    Fourier transform infrared spectra;    UV-vis spectra;    X-ray powder diffraction;    X-ray photoelectron spectroscopy;    scanning electron microscopy;    transmission electron microscopy;    TEM;    nanocomposites;    bactericidal activity;    Escherichia coli bacteria;    Staphylococcus aureus bacteria;    artificial biomedical material;    wound healing;    Ag-C;   

DOI  :  10.1049/mnl.2017.0315

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background:  Myocardial infarction has been regarded as one of the fastest killer diseases of modern-day man. Aim:  The protective effect of  Andrographis paniculata  on isoproterenol (ISO)-induced myocardial infarction in rats was investigated. Setting:  The study was carried out in a laboratory setting. Methods:  Animals were randomly divided into six groups of seven animals per group, and the treatment was as follows: normal control received normal saline for 9 days, isoproterenol group; three extract-treated groups in pre-treatment phase and an extract-treated group in post-treatment phase. The doses were given at 100, 200 and 400 mg/kg body weight for pre-treatment phase respectively while 200 mg/kg dose was given to the post-treatment phase group. Blood and heart tissues were collected for biochemical assays, haematological and histological analyses. Results:  Myocardial infarction was recorded in ISO group but was corrected by the extracts in both pre-treatment and post-treatment phases. The ISO group experienced a significant decrease in antioxidant parameters, whereas the extract at all doses caused a significant increase in the activities of in these parameters. The extract caused a significant decrease in malondialdehyde content and hydrogen peroxide generation, whereas reverse was the case for the ISO group. Although no significant histopathological changes were recorded for the extract, the ISO group showed marked histopathological changes. ISO caused higher expressions of cardiac C-reactive protein (CRP) and CTnI and decreased the expressions of IL-10β; but this was the opposite for the extract. Conclusion:  The ethanol leaf extract of  A. paniculata  significantly exhibits cardioprotective effects.

【 授权许可】

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