Synthesis, characterisation and thermo-physical investigations on magnesia nanoparticles dispersed in ethylene glycol–DI water (50:50)

Micro & nano letters

article

Suseel Jai Krishnan Sasidharan¹  Nagarajan Parasumanna Krishnamurthy¹  Rizalman Mamat²  Vimala Devi Loganathan³  Ravishankar Sathyamurthy¹ 

[1] Department of Mechanical Engineering, S. A. Engineering College;Faculty of Mechanical Engineering, Universiti Malaysia Pahang;Department of Physics, MIT Campus, Anna University

关键词: magnesium compounds;    nanoparticles;    nanofabrication;    combustion synthesis;    X-ray diffraction;    nanofluidics;    Fourier transform infrared spectra;    light scattering;    electrokinetic effects;    viscosity;    thermal conductivity;    specific heat;    thermo-physical investigations;    magnesia nanoparticles;    ethylene glycol–DI water;    solution combustion;    X-ray diffraction;    scanning electron microscopy;    magnesia dispersion;    ethylene glycol;    deionised water;    MgO;    temperature 25 degC to 60 degC;    specific heat diminution;    thermal conductivity;    volume concentration;    differential scanning calorimeter;    KD2 Pro analyser;    specific heat;    thermal conductivity;    rotational viscometer;    viscosity;    volume concentration;    Scherrer relation;    crystallite size;    average particle size;    nanofluid stability;    Zeta potential measurement;    dynamic light scattering;    Fourier transform infrared;    measurement;   

DOI  :  10.1049/mnl.2017.0484

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background:  The leaves of  Alchornea laxiflora  are traditionally used in the south of Nigeria to prevent preterm births.   Aim:  This study was designed to investigate the activity of  A. laxiflora  on uterine contractility.   Setting:  The leaves of the plant were collected from forests in Egor, Benin City, Nigeria.   Methods:  The leaves were cleaned and extracted in methanol. The extract (0.005 mg/mL–3.5 mg/mL) was tested on spontaneous uterine contraction and on oxytocin-induced contraction in normal and Ca 2+ -free media. The plant extract (0.0035 mg/mL, 0.035 mg/mL, 0.35 mg/mL and 3.5 mg/mL) was tested on high KCl-induced uterine contractions (80 mM). The plant extract (3.5 mg/mL) was also studied in the presence of amiodarone and glibenclamide in separate experiments. Mass spectrometric analysis was additionally performed on the plant extract in order to identify significant secondary metabolites that may have contributed to the activity of the plant.   Results:  The plant extract inhibited spontaneous, oxytocin and high KCl-induced uterine contractions and also significantly inhibited ( p  < 0.01) oxytocin-induced uterine contraction in Ca 2+ -free medium. The plant extract significantly inhibited ( p  < 0.01 and  p  < 0.05) oxytocin’s amplitude in the presence of amiodarone and glibenclamide, respectively. Secondary metabolites belonging to classes of fatty acids, glycols, terpenes, flavonoid glycosides and porphyrins were identified.   Conclusion:   Alchornea laxiflora  inhibited mouse uterine contractility possibly through interaction with potassium and calcium channels. Of the known metabolites identified, 3-deoxy-arabino-hept-2-ulosonic acid, 17-hydroxyingenol and phaeophorbide-a methyl inhibit uterine contractility and may contribute to the activity of  A. laxiflora  in utero.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND