Shape effect on the elastic properties of Ag nanocrystals

Micro & nano letters

article

Sumit Sarkar¹  Ratan Das¹ 

[1] Nano-Physics & Nano Technology Research Laboratory, Department of Physics, Tripura University

关键词: silver;    nanostructured materials;    crystal structure;    X-ray diffraction;    transmission electron microscopy;    stress-strain relations;    elasticity;    shape effect;    silver nanocrystals;    X-ray diffraction;    nanocubes;    nanohexapods;    chemical reduction method;    ethylene glycol;    reducing agent;    poly (vinylpyrrolidone);    stabilising agent;    high-resolution transmission electron microscope images;    face-centred cubic structure;    Williamson–Hall plot;    stress–strain plot;    Ag;   

DOI  :  10.1049/mnl.2017.0349

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background:  Cypermethrin (Cyp), a synthetic pyrethroid developed for agricultural and public health applications, has become harmful to the environment and mammalian life owing to indiscriminate use. Aim:  This study aimed to investigate the protective effect of the methanolic extract of  Jatropha gossypifolia  leaves against Cyp-induced genotoxicity in rats using alpha-lipoic acid (α-LA) as standard drug. Method:  Fifty-six male Wistar rats, assigned to eight groups of seven animals each, were treated orally for 28 days as follows - Group 1: only corn oil (Control); Group 2: 20 mg/kg body weight (b.wt) of Cyp; Groups 3, 4 and 5: Cyp + 50 mg/kg b.wt of  J. gossypifolia , Cyp + 100 mg/kg b.wt of  J. gossypifolia  and Cyp + 50 mg/kg b.wt of α-LA, respectively; Groups 6, 7 and 8:  J. gossypifolia  (50 mg/kg b.wt),  J. gossypifolia  (100 mg/kg b.wt) and α-LA (50 mg/kg b.wt), respectively. The P53 was assayed for using the plasma, while the micronucleus assay was carried out on the bone marrow. Results:  Results showed that exposure to Cyp significantly increased the number of micronucleated polychromatic erythrocytes (86.70%) as well as p53 concentration in both the liver and plasma (200.00% and 125.53%) compared to the control. Co-administration with methanolic extract of  J. gossypifolia  leaves significantly reversed these alterations in a dose-dependent manner. Conclusion:  The methanolic extract of  J. gossypifolia  leaves has the potential to ameliorate Cyp-induced genotoxicity in rats, and also, the toxicological evaluations of the plant extract and α-LA showed that it is relatively safe for use at the doses investigated.

【 授权许可】

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