Albumin nanoparticles fabricated from microscaled PLGA templates using layer-by-layer assembly

Micro & nano letters

article

Qi Zhao¹  Zhe-Xiang Fang¹  Ming-Mao Chen¹  Min Li²  Zhi-Min Zhou²  Bo Du²  Qi-Qing Zhang¹ 

[1] Institute of Biomedical and Pharmaceutical Technology, Fuzhou University;Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials

关键词: proteins;    nanoparticles;    nanofabrication;    self-assembly;    particle size;    drug delivery systems;    biomedical materials;    nanomedicine;    elastic moduli;    elastic modulus;    external sonication;    mechanical property;    solid inner structure;    spherical surface;    hollow capsules;    poly[lactic-co-(glycolic acid)];    drug delivery vehicles;    particle size;    layer-by-layer assembly;    microscaled PLGA templates;    albumin nanoparticles;   

DOI  :  10.1049/mnl.2017.0696

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In a previous study, we reported changes in the adrenocorticotropic hormone (ACTH) and cortisol secretion in blood samples from law enforcement personnel during the mission to local armed conflict region. In the present study, we demonstrate those changes collectively with additional data on changes in t he adrenaline and noradrenaline in the urine samples of the same individuals. The study was conducted on 48 male officers who were deployed to an army conflict teritory for a duration of 4 months . At the onset of the mission , there was a modest increase in all hormones corresponding to the general adaptation syndrome theory. As the mission started, significant increases were observed in the mean levels of the hormonal parameters in both serum and urine at different time points as compared to those before the mission. At first week of deployment, a sharp increase in the secretory activity of medulla and cortical adrenal gland was found and at the termination of the mission a dysfunction of hypophysis-adrenal gland regulation system was identified. These findings might lead to disturbances in interhormonal relation ships and cause decreased stress tolerance in the relevant individals .

【 授权许可】

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