Photophysical performances and morphology of phosphorescent electrospun fibres fabricated from iridium complex/PMMA blends

Micro & nano letters

article

Aihui Liang¹  Tian Cao¹  Xiulan Yang¹  Yi Chen¹  Han Wang¹  Zhiping Wang¹  Dewang Liu¹  Ming Luo¹ 

[1] Key Laboratory of Functional Small Organic Molecule, Ministry of Education and College of Chemistry and Chemical Engineering, Jiangxi Normal University

关键词: iridium compounds;    polymer blends;    polymer fibres;    electrospinning;    phosphorescence;    aggregation;    photoluminescence;    scanning electron microscopy;    surface structure;    photophysical performances;    iridium complex-PMMA blends;    yellow phosphorescent electrospun fibres;    binary blend;    poly(methyl methacrylate);    single spinneret;    geometrical confinement;    electrospinning;    aggregation;    spin-coated films;    photoluminescence quantum efficiency;    scanning electron microscopy;    surface structure;    high boiling point solvent;    N;    N-dimethylformamide;    wearable organic light-emitting diodes;   

DOI  :  10.1049/mnl.2017.0840

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Both methotrexate and vitamin D3 are used in combination for the treatment of various diseases. The aim of this study is to highlight the effect of vitamin D3 on methotrexate-induced jejunum damage using biochemical and   histopathological  studies. Seven groups of both sexes of rats were selected and treated as follows: (Group I and Group II) : control 1,control 2 (I.P normal saline) daily for 14 and 21 days respectively ; (Group III and Group IV) :vitamin D3 groups (500 IU/rat/day) orally for 14 and 21 days, respectively;(Group V): once daily dose of methotrexate 20mg/kg, I.P injected for 4 days;(Group VI):vitamin D3 (500 IU/rat/day) once daily for 14 days and methotrexate (20 mg/kg I.P) injected only at day 10;.(Group VII) vitamin D3 (500 IU/rat/day) orally for 21 days and methotrexate (20 mg/kg I.P) injected only at day 17; then the jejunum was removed and used for measuring malondialdehyde (MDA) content, total antioxidant capacity (TAOC) level; in addition histopathological study of jejunum tissue. Administration of vitamin D3 for 21 days and a single dose of methotrexate at day 17 resulted in non-significant difference (P>0.05) in MDA; while significant reduction (P<0.05) in the TAOC level in jejunum tissue; furthermore , sever villi damage ,crypts abscess, epithelial atrophy , mixed inflammatory cells infiltrate and goblet cells depletion were observed in comparison with methotrexate group. So the study demonstrates that vitamin D3 plays a synergistic role with methotrexate therefore the combined use of vitamin D3 and methotrexate may be used as a strategy to overcome dose limitations and side effects when use for the treatment of cancer, rheumatoid arthritis and psoriasis.

【 授权许可】

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