Effect of silane coating containing SiC nanoparticles on the corrosion behaviour of stainless steel 304

Micro & nano letters

article

Javad Mokhtarian¹  Alireza Allafchian²  Masoud Atapour¹ 

[1] Department of Materials Engineering, Isfahan University of Technology;Research Institute for Nanotechnology and Advanced Materials, Isfahan University of Technology

关键词: surface treatment;    X-ray diffraction;    electrochemical impedance spectroscopy;    stainless steel;    nanoparticles;    silicon compounds;    attenuated total reflection;    nanofabrication;    corrosion protective coatings;    scanning electron microscopy;    field emission electron microscopy;    corrosion resistance;    corrosion protection;    sol-gel processing;    Fourier transform infrared spectra;    SiC;    corrosion behaviour;    304 stainless steel substrate;    3-(aminopropyl) triethoxysilane;    coated substrates;    field emission scanning electron microscope;    superior corrosion resistance;    bare 304 stainless steel;    homogenous nanostructure coating;    highly adherent protective nanostructure coating;    silane coating;    scanning electron microscope;    attenuated total reflectance-Fourier transform infrared spectrometer;    X-ray diffraction;    sol–gel deposition method;    silicon carbide nanoparticles;    electrochemical impedance spectroscopy;    conducting potentiodynamic polarisation tests;    tetraethoxysilane;   

DOI  :  10.1049/mnl.2018.0049

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Abstract    Mitoxantrone is an antitumor agent used in the treatment of breast and prostate cancer, acute leukemia, lymphoma, and also in the treatment of multiple sclerosis due to its immunosuppressive properties. The mitoxantrone's cardiotoxicity is irreversible, dose-dependent, and it may occur years after treatment. Zinc is considered as an essential mineral for cell division and the synthesis of DNA and protein; furthermore, such mineral has an important role in states of cardiovascular diseases; and may have protective effects in coronary artery disease and cardiomyopathy. Objective: The current study is designed to investigate effects of two different doses of zinc sulfate on mitoxantrone-induced cardiotoxicity in rats. Methods: Forty-eight (48) adult rats of both sexes were utilized in this study; the animals were randomly divided into six groups of 8 animals each. Group I: distilled water (negative control). Group II: orally-administered zinc sulfate (15mg/kg/day) Group III: orally-administered zinc sulfate (30mg/kg/day) Group IV: Intraperitoneally injected with a mitoxantrone at a dose (2.5 mg/kg) to reach total cumulative dose of 7.5 mg/kg on day 20. Group V: Orally-administered zinc sulfate at a dose (15mg/kg/day) and an intraperitoneal injection of mitoxantrone at a dose (2.5 mg/kg) was administered to reach total cumulative dose of 7.5 mg/kg on day 20. Group VI: Orally-administered zinc sulfate at a dose (30 mg/kg/day), and an intraperitoneal injection of mitoxantrone at a dose (2.5 mg/kg) to reach total cumulative dose of 7.5 mg/kg on day 20. Forty-eight (48) hr after the end of treatment duration (i.e. at day 22 nd), each animal was euthanized by diethyl ether and ketamine. Then, after cervical dislocation, blood was obtained by intracardiac puncture and then serum was prepared to estimate cardiac troponin I 3 enzyme activity levels; and the heart of each animal was excised for homogenate preparation to estimate of malondialdehyde contents. Results: Oral administration of zinc sulfate [(15mg/kg/day with total cumulative dose (7.5 mg/kg) of mitoxantrone] (Group V) resulted in a non-significant (P>0.05) difference in serum activity level of troponin I 3 enzyme and malondialdehyde contents in cardiac tissue homogenate compared to the corresponding serum enzyme activity level and contents in group of rats intraperitoneally injected with total cumulative dose of 7.5 mg/kg of mitoxantrone (Group IV). In contrast, there were significant reduction (P<0.05) in serum activity level of troponin I 3 enzyme and malondialdehyde contents in cardiac tissue homogenate of rats orally-administered zinc sulfate [(30 mg/kg/day) with total cumulative dose (7.5mg/kg) of mitoxantrone] (Group VI) compared to the corresponding enzyme activity levels and contents in group of rats intraperitoneally-injected with total cumulative dose of 7.5mg/kg of mitoxantrone (Group IV). Conclusion: zinc sulfate at a dose (30 mg/kg/day) diminishes the cardiotoxicity induced by mitoxantrone via a free radical scavenger property but it is non signifant compared to (15 mg/kg/day) .

【 授权许可】

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