Facile synthesis of nano-structured SnO 2 films and their properties in ethanol gas sensing

Micro & nano letters

article

Ying Wang¹  Hongbin Yu¹  Hui Suo²  Xinhong Wang³  Ying Lu¹  Suiyi Zhu¹  Xia Yang¹ 

[1]School of Environment, Engineering Lab for Water Pollution Control and Resources Recovery, Northeast Normal University

[2]College of Electronic Science & Engineering, Jilin University

[3]College of Resources and Environment, Jilin Agricultural University

关键词: tin compounds;    nanosensors;    nanowires;    X-ray photoelectron spectra;    scanning electron microscopy;    semiconductor growth;    gas sensors;    nanofabrication;    X-ray diffraction;    semiconductor thin films;    organic compounds;    facile one-step hydrothermal method;    Ti substrate;    mercaptoacetic acid;    adjusting reagent;    X-ray diffractometer;    X-ray photoelectron spectroscopy;    XPS;    ethanol gas sensing;    organic reagents;    gas sensing experiments;    gas sensing properties;    facile synthesis;    nanostructured SnO2 films;    scanning electron microscope;    nanoscaled morphologies;    nanowires;    nanonets;    transparent nanosheets;    nanograsses;    SnO2;    Ti;   

DOI  :  10.1049/mnl.2017.0806

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Atorvastatin (ATR) is poorly soluble anti-hyperlipidemic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Solid dispersions adsorbate is an effective technique for enhancing the solubility and dissolution of poorly soluble drugs.           The present study aims to enhance the solubility and dissolution rate of ATR using solid dispersion adsorption technique in comparison with ordinary solid dispersion. polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), Poloxamer188 and Poloxamer 407were used as hydrophilic carriers and Aerosil 200, Aerosil 300 and magnesium aluminium silicate (MAS) as adsorbents.            All solid dispersion adsorbate (SDA) formulas  were prepared in ratios of 1:1:1  (drug: carrier: adsorbent) and evaluated for their water solubility, percentage yield, drug content,  , dissolution, crystal structure using  X-ray powder diffraction (XRD) and Differential Scanning Calorimetry (DSC)  studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier- adsorbate interaction.                The prepared (SDA) showed significant improvement of drug solubility in all prepared formula. Best result was obtained with formula SDA12(ATR :Poloxamer407 : MAS 1:1:1) that showed 8.07 and 5.38  fold increase in solubility compared to  solubility of pure ATR and  solid dispersion(SD4) (Atorvastatin: Poloxamer 407 1:1) respectively due to increased wettability and reduced crystallinity of the drug which leads to improve drug solubility  and  dissolution .

【 授权许可】

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