Wafer-level fabrication of low power consumption integrated alcohol microsensor

Micro & nano letters

article

Hairong Wang¹  Mengya Wang¹  Weitao Lei¹  Xiaowei Chen¹  Hao Huang¹  Jiuhong Wang¹ 

[1] School of Mechanical Engineering, Xi'an Jiaotong University;State Key Laboratory for Manufacturing Systems Engineering

关键词: micromachining;    membranes;    sputter deposition;    microsensors;    gas sensors;    nanocomposites;    power consumption;    organic compounds;    power measurement;    nanosensors;    temperature sensors;    temperature measurement;    titanium compounds;    tin compounds;    suspensions;    electrochemical electrodes;    wafer-level sensor chips;    alcohol detection;    wafer-level fabrication;    microheater;    magnetron sputtering;    electrodes;    suspended membrane;    nanocomposites;    microelectromechanical systems micromachining technology;    low power consumption integrated alcohol microgas sensor;    power 39.0 mW;    TiO2-SnO2;   

DOI  :  10.1049/mnl.2018.5183

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Hypertension is one of the main causes of heart disease; beta- blockers play a crucial role in the management of patients with essential hypertension. Bisoprolol is one of the widely used drugs for the treatment of hypertension. Bisoprolol tablets were prepared by two methods (direct and wet) using different proportion and types of diluents, different binder types and forms, then evaluated for, weight variation, hardness, friability, disintegration time and dissolution rate. The results were compared with a reference Bisoprolol tablet. Both methods of preparation wet and direct compression method gave good results, which are consistent with the requirements of British Pharmacopeia and United States Pharmacopeia. It was found that the type of diluent (mannitol and lactose), binder type (polyvinyl pyrrolidone and acacia) and the presence of starch as a disintegrant affect the hardness, disintegration and the dissolution rate of the tablet. While liquid binder (polyvinyl pyrrolidone solution) gave longer disintegration time (12 min) with higher hardness compared with the powdered binder (polyvinyl pyrrolidone powder) that gave (5 min). The results indicate that formula F1 which consists of [Mannitol (65mg)/ Avicel 102 (26 mg), starch and magnesium stearate] showed the best results as it has lower disintegration time (2.7 min), faster dissolution rate (100% release within 20 min) and prepared by a low cost method (direct method).

【 授权许可】

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