AgCl/AgIO 4 composites as an efficient photocatalyst for visible-light-driven degradation of rhodamine B

Micro & nano letters

article

Xiang-Feng Wu¹  Yi-Jin Wang¹  Hui Li¹  Chen-Xu Zhang¹  Jia-Rui Zhang¹  Jun-Zhang Su¹  Yi-Wei Wang¹  Zuo-Lin Cao¹  Kai-Yuan Wang¹  Mi Zhang¹ 

[1] School of Materials Science and Engineering, Hebei Provincial Key Laboratory of Traffic Engineering Materials, Shijiazhuang Tiedao University

关键词: scanning electron microscopy;    transmission electron microscopy;    ultraviolet spectra;    X-ray photoelectron spectra;    X-ray diffraction;    electrochemical impedance spectroscopy;    visible spectra;    catalysis;    photochemistry;    silver compounds;    dyes;    visible-light-driven degradation;    X-ray diffraction;    transmission electron microscopy;    UV–vis diffuse reflectance spectroscopy;    X-ray photoelectron spectroscopy;    electrochemical impedance spectroscopy;    visible light irradiation;    degradation efficiency;    photocatalyst;    photocatalytic activity;    photocatalytic degradation mechanism;    rhodamine B;    AgCl/AgIO4 composite;    scanning electron microscopy;    time 30.0 min;    electron volt energy 1.21 eV;    AgCl/AgIO4;   

DOI  :  10.1049/mnl.2018.5185

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Mefenamic acid (MA) is one of the non-steroidal anti-inflammatory drugs, it is widely used probably due to having both anti-inflammatory and analgesic activity, the main side effects of mefenamic acid include gastrointestinal tract (GIT) disturbance mainly diarrhea, peptic ulceration, and gastric bleeding. The analgesic effects of NSAIDs are probably linked to COX-2 inhibition, while COX-1 inhibition is the major cause of this classic adverse effects. Introduction of thiazolidinone may lead to the increase in the bulkiness leads to the preferential inhibition of COX-2 rather than COX-1 enzyme. The study aimed to synthesize derivatives of mefenamic acid with more potency and to decrease the drug's potential side effects, new series of 4-thiazolidinone derivatives of mefenamic acid were synthesized IVa-g. The synthetic procedures for target compounds and their intermediates are designed to be as follows: acylation of secondary amine of mefenamic acid by chloroacetylchloride to produce compound (I), then reaction between compound (I) and hydrazine hydrate to form hydrazine derivative of mefenamic acid (compound II). After that, Schiff base formation by addition of seven benzaldehyde derivatives and finally, cyclization in presence of thioglycolic acid to form 4-thiazolidinone heterocyclic ring. The characterization of the titled compounds has been established on the basis of their spectral FTIR, 1HNMR data, and by measurements of their physical properties. In vivo acute anti-inflammatory effect of the synthesized compounds was evaluated in rats using egg-white induced edema model of inflammation. The tested compounds and the reference drug produced significant reduction of paw edema with respect to the effect of dimethyl sulfoxide 10%v/v (control group). Compound IVe showed more potent effect than mefenamic acid at 240-300 min, while at time 300 min, compounds IVa and IVd exhibit more potent anti-inflammatory effect than mefenamic acid (50mg/kg, i.p.) as they reduced paw edema significantly more than mefenamic acid at mentioned intervals (p<0.05) . On the other hand compound IVc exhibited lower anti-inflammatory effect.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND