Micro & nano letters | |
Fabrication of microparabolic reflector for infrared antenna coupled detectors | |
article | |
Mohamed H. Mubarak1  Othman Sidek1  Mohamed R. Abdel-Rahman2  Mohamed Tafir Mustaffa1  Ahmed Shukri Mustapa Kamal3  Saad M. Mukras4  | |
[1] School of Electrical and Electronic Engineering, Universiti Sains Malaysia;Electrical Engineering Department, King Saud University;School of Physics, Universiti Sains Malaysia;Mechanical Engineering Department, Qassim University | |
关键词: etching; masks; infrared detectors; reflector antennas; micro-optics; optical fabrication; xenon compounds; XeF2; masking pattern; etching technique; infrared antenna coupled detectors; optimum etching recipe; isotropic xenon difluoride; resultant parabolic cavities; proper patterning mask; pattern dependency problem; structure design; proper etching recipe; microparabolic reflector; | |
DOI : 10.1049/mnl.2017.0826 | |
学科分类:计算机科学(综合) | |
来源: Wiley | |
【 摘 要 】
Small molecules drug conjugate mutual prodrug design (SMDC) composed of folate and lethal agent conjugate, rigidly bonded via hydrophilic bridge and self immolative disulfide bond ; represent new interesting approaches for cancer treatment , the component of SMDC intended for targeting folate receptor , along with greater conservation of component until reaching the target tumor tissue . The designing and synthesis of compound VI and VIII derived from 6-Mercaptopurine (6-MP) and Methotrexate ( MTX) conjugate altogether as mutual prodrugs were processed forward successfully by multistep reaction procedures , and by Thin Layer Chromatography (TLC) for preliminary detection of products and their intermediates, along with their purity. The structures of two final compounds and their intermediates were proclaimed by melting point measurement, infrared spectrometry and ¹HNMR analysis given results greatly correspond with theoretical proposed chemical structure of synthesized compounds. Furthermore, cytotoxic activity evaluation on cell line level had been done for two final compounds against human breast tumor cell (MCF-7) and human ovarian tumor cell (SKO-3) types of cancer cell line and the results were confirmed which show greater cytotoxic tumor activity of two final compounds, while compound VI possess optimal activity proportional with increased number of 6-MP molecules.
【 授权许可】
CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND
【 预 览 】
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RO202107100003037ZK.pdf | 447KB | download |