Low-cost microfluidics: materials and methods

Micro & nano letters

article

Yiqiang Fan¹ 

[1] School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology

关键词: clean rooms;    polymers;    microfabrication;    microfluidics;    low-cost microfluidics;    low-cost fabrication methods;    material cost;    fabrication cost;    low-cost fabrication technologies;    energy field;    microelectromechanical systems;    integrated circuit industry;    cleanroom environment;    polymers;    paper materials;    microfabrication process;    material cost reduction;    bonding technologies;   

DOI  :  10.1049/mnl.2018.5169

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Many reports confirm ulcers as an adverse effect of drugs such as nicorandil and aspirin. The exact responsible mechanisms of ulceration have until now not proved. Mucosal ulcers associated with the onset of ulcer are manifested by an increase in proinflammatory cytokine, excessive prostaglandin, and up-regulation of Endothilin-1 level, which directly impacts the release of leptin. These, released locally within mucosal tissues, have played a role in controlling the extent of local inflammatory responses and processes of mucosal repair.This study was designed to find out the correlation of plasma leptin and prostaglandin levels as a possible mechanism of oral ulcer formation as an adverse effect of nicorandil. The effect of nicorandil for inducing ulceration was assessed. The plasma leptin and prostaglandin E2 for the tested groups in relation to the studied parameters (gender, and daily body weight change) were estimated in albino rats.Nicorandil causes mucous membrane damage, inflammation, and ulceration. A significant reduction of plasma leptin level, which was dose-dependent, and a non-significant reduction of serum prostaglandin E2 level. The mechanisms of ulcer induction as an adverse effect of nicorandil can be related to dose-dependant leptin and prostaglandin E2 levels, which affects on repair and healing process.Keywords: Nicorandil, Leptin, Prostaglandin E2, Ulcer.

【 授权许可】

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