Facile synthesis of Ag 3 PO 4 microcrystals and its enhanced photocatalytic disinfection

Micro & nano letters

article

Chi-Shun Tseng¹  Tsunghsueh Wu²  Yang-Wei Lin¹ 

[1] Department of Chemistry, National Changhua University of Education;Department of Chemistry, University of Wisconsin-Platteville, 1 University Plaza

关键词: antibacterial activity;    adsorption;    ultraviolet spectra;    photochemistry;    catalysis;    scanning electron microscopy;    silver compounds;    crystal growth from solution;    microorganisms;    scanning electron microscopy;    silver phosphate microcrystals;    photocatalytic disinfection;    UV-visible diffuse reflectance spectroscopy;    antibacterial activity;    Escherichia coli;    Staphylococcus aureus;    white-light light-emitting-diode irradiation;    adsorption;    time 10.0 min;    Ag3PO4;   

DOI  :  10.1049/mnl.2018.5049

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

An oral bi layer  sustained release (SR) strips of Sodium  Montelukast SMLT , which is selective  leukotriene  antagonist  , used  for  patients  suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar  gum , carrageenan , and xanthan gum , by solvent casting method . The results obtained by this study revealed  ,that best  fast  dissolving  film of  SMLT was  loaded  in carrageenan   polymer 57%  w\w (30mg.) ,  with  acceptable  physical properties, like film thickness , elastic endurance and  surface pH  . Besides  to that , the  disintegration  time , and  cumulative  80%   drug  release  were estimated  22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 )  as a second layer , appear to be the most promised  layer of SMLT loaded in 50 % w\w  (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH . Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release  was 15 minutes  extended  for 4hours of 100% drug release . Meanwhile , the  investigation of possible  interference  between the  drug , and, polymers used  revealed  no evidence of this effect ,using FTIR  , and SEM  technique . In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet  as a marketed product was used , the result gave  more  than 4 hours  of  selected formula , compared with  30 minutes to marketed product Singulair® . The overall results candidates  the selected  FSR6-7  formula  as a promised  bi layer buccal fast , as compliance  and  extended therapy for asthmatic mid- night patients.

【 授权许可】

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