Preparation and characterisation of poly(butylene succinate) microcarriers containing pesticide

Micro & nano letters

article

Yakun Liu¹  Baohua Guo¹ 

[1] Advanced Materials Laboratory of Ministry of Education, Department of Chemical Engineering, Tsinghua University

关键词: encapsulation;    evaporation;    phase separation;    chromatography;    materials preparation;    particle size;    agrochemicals;    polymer blends;    biodegradable materials;    drugs;    microfabrication;    solvents (industrial);    solvent evaporation induced phase separation method;    narrow particle size distribution;    pesticide content;    high-performance liquid chromatography;    pesticide formulations;    poly(butylene succinate) microcarriers;    drug stability;    agriculture development;    biodegradable poly(butylene succinate) microspheres;    λ-cyhalothrin;   

DOI  :  10.1049/mnl.2018.5060

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The purpose of this research work is to synthesize conjugates of some NSAIDs with sulfamethoxazole as possible mutual prodrugs to overcome the local gastric irritation of NSAID with free carboxyl group by formation of ester linkage that supposed to remain intact in stomach and may hydrolyze in intestine chemically or enzymatically; in addition to that attempting to target the synthesized derivative to the colon by formation of azo group that undergo reduction only by colonic bacterial azo reductaze enzyme to liberate the parent compound to act locally (treatment of  inflammation and infections in colon).

【 授权许可】

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