Preparation of CQDs with hydroxyl function for Fe 3+ detection

Micro & nano letters

article

Limin Dong¹  Wanqi Zhang¹  Xuejiao Li¹  Xiaoyao Geng¹ 

[1] Heilongjiang Department of Education, College of Materials Science and Engineering, Harbin University of Science and Technology;Key Laboratory of Engineering Dielectrics and its Application, Ministry of Education, Harbin University of Science and Technology

关键词: carbon;    fluorescence;    quantum dots;    radiation quenching;    nanofabrication;    nanostructured materials;    microwave materials processing;    C;    nanostructured materials;    ethanol;    agglomeration;    up-conversion fluorescence properties;    fluorescence stability;    Fe3+ detection;    fluorescence intensity;    fluorescence quenching;    metal ion detection;    hydrothermal method;    solvothermal method;    microwave method;    carbon-quantum dots;    hydroxyl function;   

DOI  :  10.1049/mnl.2018.5369

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

This study aims to encapsulate atenolol within floating alginate-ethylcellulose beads as an oral controlled-release delivery system using aqueous colloidal polymer dispersion (ACPD) method.To optimize drug entrapment efficiency and dissolution behavior of the prepared beads, different parameters of drug: polymer ratio, polymer mixture ratio, and gelling agent concentration were involved.The prepared beads were investigated with respect to their buoyancy, encapsulation efficiency, and dissolution behavior in the media: 0.1 N HCl (pH 1.2), acetate buffer (pH 4.6) and phosphate buffer (pH 6.8). The release kinetics and mechanism of the drug from the prepared beads was investigated.All prepared atenolol beads remained floating on 0.1 N HCl (pH 1.2) medium over 24 hours. Besides, high yield beads of 73.07- 84.31% was obtained. Encapsulation efficiencies were in the range of 33.10 % -79.04 %, and were found to increase as a function of increasing drug: polymer mixture ratio and the gelling agent concentrations.Moreover, atenolol release profile from the beads was affected by the pH of the dissolution medium. It was found to be slowest in 0.1 N HCl (pH 1.2) and fastest in phosphate buffer (pH 6.8).The obtained results suggest that atenolol could be formulated as a controlled release beads, using ethylcellulose and alginate as polymers, using ACPD method.

【 授权许可】

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