Fabrication and improvement of PCL/alginate/PAAm scaffold via selective laser sintering for tissue engineering

Micro & nano letters

article

Jinzhe Wu¹  Runhuai Yang²  Jinjin Zheng¹  Linxin Pan³  Xiaoying Liu³ 

[1] Department of Precision Machinery and Precision Instrument, University of Science and Technology of China;Department of Biomedical Engineering, School of Life Science, Anhui Medical University;Department of Biology, School of Life Science, Anhui Medical University

关键词: laser sintering;    tissue engineering;    porous materials;    elastic moduli;    bone;    elongation;    biomedical materials;    cellular biophysics;    biological tissues;    elasticity;    polymer blends;    selective laser sintering;    tissue engineering;    porous polycaprolactone scaffolds;    critical processing parameters;    experiment mechanical property assessment;    PCL-alginate-polyacrylamide scaffold;    cell seeding;    in vitro culture;    cell viability;    SLS technique;    skeletal tissue repair;    elastic modulus;   

DOI  :  10.1049/mnl.2018.5806

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, porous polycaprolactone (PCL) scaffolds were designed and fabricated using selective laser sintering (SLS). The critical processing parameters of the SLS for PCL were optimised. This work post-processed these PCL scaffolds to produce PCL/alginate/polyacrylamide (PAAm) scaffolds to improve their performance. The experiment mechanical property assessment showed that the sample's average elastic modulus increases from 6.99 MPa (PCL) to 12.67 MPa (PCL/alginate/PAAm), and the elongation at break of samples increases from 59% (PCL) to 112.9% (PCL/alginate/PAAm). Cell seeding and in vitro culture showed that cell viability remained above 94% over 5 days. Thus, the current study suggests that a promising strategy for the improvement of the characteristics of PCL/alginate/PAAm scaffolds and advances the potential application of SLS technique towards skeletal tissue repair.

【 授权许可】

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