Surface-enhanced Raman spectroscopy with gold nanoparticle dimers created by sacrificial DNA origami technique

Micro & nano letters

article

Naoki Yamashita¹  Seongsu Park¹  Kentaro Kawai²  Yoshikazu Hirai¹  Toshiyuki Tsuchiya¹  Osamu Tabata¹ 

[1] Department of Microengineering, Graduate School of Engineering, Kyoto University;Department of Precision Science and Technology, Graduate School of Engineering, Osaka University

关键词: molecular biophysics;    DNA;    nanosensors;    surface enhanced Raman scattering;    nanoparticles;    gold;    silicon;    elemental semiconductors;    surface cleaning;    biological techniques;    chemical sensors;    chemical variables measurement;    surface-enhanced Raman spectroscopy;    gold nanoparticle dimers;    sacrificial DNA origami technique;    nanometre-scale gap;    surface-clean AuNP dimers;    SERS-based molecular detection;    Raman signals;    vacuum ultraviolet light;    ultrapure water rinsing;    4;    4′-bipyridine;    size 30.0 nm;    Au;   

DOI  :  10.1049/mnl.2019.0416

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In a previously proposed method for molecular detection based on surface-enhanced Raman spectroscopy (SERS), gold nanoparticle (AuNP) dimers are formed on a substrate using DNA origami with a nanometre-scale gap between them. In this sacrificial DNA origami technique, a conjugate of two AuNPs and a DNA origami is deposited on a silicon chip, and then the DNA origami is selectively removed using vacuum ultraviolet light and ultrapure water rinsing to form surface-clean AuNP dimers. The performance of SERS-based molecular detection of AuNP dimers created using the proposed technique with a 30 nm AuNP diameter has now been evaluated. The Raman signals from the target molecules (4,4′-bipyridine) were greatly enhanced and thus successfully detected.

【 授权许可】

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