Non-enzymatic electrochemical detection of dopamine in blood serum based on porous nitrogen-doped graphene/Fe 3 O 4 nanocomposites

Micro & nano letters

article

Yichi Wang¹  Weiqin Sheng¹  Jun Wu¹  Junming Xu¹  Kaixin Song¹ 

[1] School of Electronic Information, Hangzhou Dianzi University

关键词: nanocomposites;    electrochemical sensors;    electrochemical impedance spectroscopy;    biosensors;    electrochemical electrodes;    iron compounds;    voltammetry (chemical analysis);    nanosensors;    nanofabrication;    chemical variables measurement;    biological techniques;    biomedical transducers;    nanoporous materials;    graphene compounds;    biomedical electrodes;    nonenzymatic electrochemical detection;    dopamine detection;    glassy carbon electrode;    phenethylamine families;    cyclic voltammetry;    electrochemical impedance spectroscopy;    differential pulse voltammetry;    linear sweep voltammetry;    human blood serum;    nanocomposites;    DA biosensor;    catecholamine families;    C-Fe3O4-CON;   

DOI  :  10.1049/mnl.2020.0121

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Fe 3 O 4 with different shapes are reported herein to modify the glassy carbon electrode and then they are used to detect dopamine (DA), a member of the catecholamine and phenethylamine families. Cyclic voltammetry, electrochemical impedance spectroscopy, differential pulse voltammetry and linear sweep voltammetry are all chosen to characterise the sensor's performance to DA. Under the optimal conditions, the modified sensor (N-rGO/Fe 3 O 4 NRs/GCE) had some good performance, followed as short response time (∼3 s), wide linear range (0.2–176 μM), low detection limit (0.05 μM, S/N = 2), good stability and reproducibility. The fabricated DA biosensor was further investigated for DA determination in human blood serum, suggesting its great potential in biological samples.

【 授权许可】

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