Anticancer, antimicrobial, and dye degradation activity of biosynthesised silver nanoparticle using Artemisia kopetdaghensis

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Mohammad Ehsan Taghavizadeh Yazdi¹  Majid Darroudi³  Mohammad Sadegh Amiri⁴  Hasan Ali Hosseini⁵  Fahimeh Nourbakhsh²  Mohammad Mashreghi⁶  Malihe Farjadi²  Seyed Mousa Mousavi Kouhi⁷  Seyed Hadi Mousavi² 

[1] Student Research Committee, Mashhad University of Medical Sciences;Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences;Nuclear Medicine Research Center, Mashhad University of Medical Sciences;Department of Biology, Payame Noor University;Chemistry Department, Payame Noor University;Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences;Department of Biology, Faculty of Sciences, University of Birjand;Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences

关键词: toxicology;    antibacterial activity;    transmission electron microscopy;    ultraviolet spectra;    biomedical materials;    catalysis;    nanoparticles;    visible spectra;    microorganisms;    silver;    dyes;    cellular biophysics;    cancer;    X-ray diffraction;    spectrophotometry;    liver;    nanofabrication;    nanomedicine;    Fourier transform infrared spectra;    Fourier transform infrared spectra;    dye degradation activity;    green-synthesised Ak-AgNPs;    Artemisia kopetdaghensis;    biosynthesised silver nanoparticle;    ultraviolet-visible spectrophotometry;    XRD;    Fourier transform infrared spectra;    Streptococcus pyogenes;    Staphylococcus epidermidis;    Escherichia coli;    Klebsiella pneumoniae;    Pseudomonas aeruginosa;    Staphylococcus aureus;    human hepatocellular cancer cell line;    HepG2 cancer cells;    methylene blue;   

DOI  :  10.1049/mnl.2020.0387

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Biosynthesis of nanoparticles (NPs) is gaining attention due to the presence of functional plant macromolecules that benefit from NPs’ synthesis and also due to their exceptional bioactive compounds. Artemisia kopetdaghensis extract acted as a reducing/capping agent. Characterisation of greener-synthesised AgNPs (Ak-AgNPs) was performed by various techniques, such as Ultraviolet (UV)−visible spectrophotometry, TEM, Fourier transform infrared, and XRD. Ak-AgNPs indicated great bactericidal properties in terms of zone of inhibition (ZI) against all of the pathogenic bacteria (i.e. Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa , Streptococcus pyogenes , Staphylococcus epidermidis , and Staphylococcus aureus ). The maximum ZI of Ak-AgNPs was 22.3 and 17.8 mm against K. pneumoniae and S. aureus , respectively. Anti-proliferative activity of Ak-AgNPs on human hepatocellular cancer cell line (HepG2) using the MTT test showed dosage-dependent inhibition activity of Ak-AgNPs against HepG2 cancer cells. Also, green-synthesised Ak-AgNPs showed catalytic properties under UV-light in organic dye (methylene blue) degradation. This study revealed that the green-synthesised AgNPs using A. kopetdaghensis shoots extract had antibacterial and catalytic activities. Also, Ak-AgNPs had anti-proliferative potential against human liver cancer cell lines. The green-synthesised Ak-AgNPs have the potential to be exploited in anti-bacterial, anticancer, and biocatalyst technologies.

【 授权许可】

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