Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low-dose methylprednisolone

IJU Case Reports

article

Ryo Tanaka¹  Yoichi Kakuta¹  Koichi Tsutahara¹  Masahiro Nakagawa¹  Naotsugu Ichimaru²  Katsuhiko Sakaguchi²  Taigo Kato³  Ryoichi Imamura³  Norio Nonomura³  Tetsuya Takao¹ 

[1] Department of Urology;Kidney Center, Sumitomo Hospital;Department of Urology, Osaka University Graduate School of Medicine

关键词: COVID-19;    immunosuppressive therapy;    kidney transplantation;    low-dose methylprednisolone;    solid organ transplant;   

DOI  :  10.1002/iju5.12226

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low-dose mPSL. Case presentation A 36-year-old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground-glass shadow on both lungs, and the coronavirus disease 2019 real-time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C-reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low-dose methylprednisolone (40 mg/day) was administered for 4 days and his C-reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real-time polymerase chain reaction test was negative and the pulmonary shadow disappeared. Conclusion Low-dose methylprednisolone may prevent the development of severe coronavirus disease 2019.

【 授权许可】

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