Protein biomarkers for male artificial insemination subfertility in bovine spermatozoa

Reproductive medicine and biology

article

Hiroshi Harayama¹  Kenta Minami¹  Kazumi Kishida²  Taichi Noda³ 

[1] Division of Animal Science, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University;Department of Obstetrics and Gynecology, Shiga University of Medical Science;Research Institute for Microbial Diseases, Osaka University

关键词: acrosome;    artificial insemination;    cattle;    sperm;    subfertility;   

DOI  :  10.1002/rmb2.12021

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background Although artificial insemination (AI) technique is an established biotechnology for bovine reproduction, the results of AI (conception rates) have a tendency to decline gradually. To our annoyance, moreover, AI-subfertile bulls have been occasionally found in the AI centers. To resolve these serious problems, it is necessary to control the sperm quality more strictly by the examinations of sperm molecules. Methods We reviewed a number of recent articles regarding potentials of bovine sperm proteins as the biomarkers for bull AI-subfertility and also showed our unpublished supplemental data on the bull AI-subfertility associated proteins. Main findings Bull AI-subfertility is caused by the deficiency or dysfunctions of various molecules including regulatory proteins of ATP synthesis, acrosomal proteins, nuclear proteins, capacitation-related proteins and seminal plasma proteins. Conclusion In order to control the bovine sperm quality more strictly by the molecular examinations, it is necessary to select suitable sperm protein biomarkers for the male reproductive problems which happen in the AI centers.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND