Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen-thawed embryo transfer

Reproductive medicine and biology

article

Kazuki Saito¹  Maki Fukami¹  Mami Miyado¹  Ichiro Ono³  Keijiro Sumori³ 

[1] Department of Molecular Endocrinology, National Research Institute for Child Health and Development;Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University;Department of Obstetrics and Gynecology, Ome Municipal General Hospital

关键词: artificial cycle;    cervical heterotopic pregnancy;    frozen-thawed embryo transfer;    placenta accreta;    progesterone;   

DOI  :  10.1002/rmb2.12064

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Case A 39-year-old woman presented with a genital hemorrhage at 5 weeks of gestation after an artificial cycle double frozen-thawed embryo transfer. She was diagnosed with a cervical heterotopic pregnancy. Although hormone supplementation was discontinued to terminate the pregnancy at 5 weeks of gestation, the intrauterine and cervical gestational sacs continued to develop. Outcome The cervical gestational sac was surgically removed and the intrauterine pregnancy continued uneventfully, except for vasa previa. At 36 weeks of gestation, the patient underwent a cesarean section and gave birth to a healthy female infant. At the delivery, massive bleeding occurred and a hysterectomy was performed due to total placenta accreta. Conclusion This case provides a novel example of a near-term delivery after a cervical heterotopic pregnancy and emphasizes the need for intensive care, even after the successful management of a cervical pregnancy. Most importantly, the present case implies a possible link between hormonal withdrawal and abnormal placentation.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND