Concentration of stromal cell-derived factor-1 (SDF-1/CXCL12) in the follicular fluid is associated with blastocyst development

Reproductive medicine and biology

article

Akemi Nishigaki¹  Tomoko Tsuzuki-Nakao¹  Takeharu Kido¹  Naoko Kida¹  Maiko Kakita-Kobayashi¹  Hiromi Murata¹  Hidetaka Okada¹ 

[1] Department of Obstetrics and Gynecology, Kansai Medical University

关键词: blastocyst development;    embryo quality;    follicular fluid;    SDF‐1/CXCL12;    vascular endothelial growth factor;   

DOI  :  10.1002/rmb2.12259

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose: To study the association between stromal cell‐derived factor‐1 (SDF‐1/ CXCL12) and vascular endothelial growth factor (VEGF) concentrations in individual human ovarian follicles and IVF outcomes. Methods: Concentrations of SDF‐1 and VEGF in 261 follicular fluid samples were measured with enzyme‐linked immunosorbent assay. IVF outcome parameters were included in fertilization rate, cleavage rate, embryo morphology on day 3, and blasto‐ cyst morphology on day 5. Results: The follicular concentration of SDF‐1 and VEGF was not significantly associ‐ ated with fertilization and cleavage outcome, and embryo morphology. The rates of full blastocysts and good‐quality blastocysts were significantly higher in follicles with an SDF‐1 concentration of 275‐350 pg/mL than in the follicles with SDF‐1 concentra‐ tions of <200 and ≥350 pg/mL (P < 0.05). The follicular concentration of VEGF was not associated with the blastocyst morphology. Conclusion: Our findings showed that follicular concentration of SDF‐1, and not VEGF, may be a valuable biochemical marker of blastocyst development.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND