Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Biology of Sex Differences

Hao Zhang¹  Ziyi Zhou¹  Lishun Liu¹  Xiping Xu¹  Tengfei Lin¹  Yun Song²  Yong Huo³  Xiaoshu Cheng⁴  Ping Li⁴  Huan Hu⁴  Huihui Bao⁴  Xiao Huang⁴  Lihua Hu⁵  Xiaobin Wang⁶  Hai Ma⁷  Binyan Wang⁸  Chongqian Fang⁹  Chonglei Bi⁹  Ping Wang^1,10 

[1] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua East Road, Beijing, China;Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua East Road, Beijing, China;Institute of Biomedicine, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui Province, China;Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Beijing, China;Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province, China;Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, No. 1 Minde Road, Nanchang, Jiangxi Province, China;Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province, China;Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Beijing, China;Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 3400 N. Charles Street, 21205, Baltimore, MD, USA;Health and Family Planning Commission, No. 688 Qingshan East Road, Rongcheng, Shandong Province, China;Institute of Biomedicine, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui Province, China;Shenzhen Evergreen Medical Institute, No. 16 Gaoxin Middle 1 Road, Shenzhen, China;People’s Hospital of Rongcheng, No. 298 Chengshan Avenue, Rongcheng, Shandong Province, China;School of Public Health (Shenzhen), Sun Yat-Sen University, No. 135 Xingang West Road, Guangzhou, Guangdong Province, China;

关键词: Selenium;    First stroke;    First ischemic stroke;    First hemorrhagic stroke;    Vitamin E;   

DOI  :  10.1186/s13293-021-00383-2

来源: Springer

【 摘 要 】

BackgroundTo date, there is no clearly defined association between plasma selenium levels and first stroke. We aimed to investigate the association between baseline plasma selenium and first stroke risk in a community-based Chinese population.MethodsUsing a nested case-control study design, a total of 1255 first stroke cases and 1255 matched controls were analyzed. Participant plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the association of plasma selenium with first stroke risk was estimated by conditional logistic regression models.ResultsOverall, a non-linear negative association between plasma selenium and first total stroke and first ischemic stroke risks was found in males but not in females. Compared with participants with lower selenium levels (tertile 1–2, < 94.1 ng/mL), participants with higher selenium levels (tertile 3, ≥ 94.1 ng/mL) had significantly lower risks of first total stroke (OR 0.63; 95% CI 0.48, 0.83) and first ischemic stroke (OR 0.61; 95% CI 0.45, 0.83) in males but not in females with first total stroke (OR 0.92; 95% CI 0.69, 1.22) and first ischemic stroke (OR 0.89; 95% CI 0.65, 1.22). Furthermore, a stronger association between plasma selenium and first total stroke was found in males with higher vitamin E levels (≥ 13.5 μg/mL vs. < 13.5 μg/mL P-interaction = 0.007). No significant association was observed between plasma selenium and first hemorrhagic stroke risk in either males or females.ConclusionOur study indicated a significant, non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274.

【 授权许可】

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