Effects of Selenium Supplementation on Soluble FMS-Like Tyrosine Kinase-1 and Glutathione Peroxidase Levels and the Plasminogen Activator Inhibitor-1: Plasminogen Activator Inhibitor-2 Ratio in Pregnant Women

lranian journal of Clinical Infectious Diseases

Elahe Heidari¹  Fatemeh Tara⁵  Gordon Ferns⁶  Margaret P. Rayman⁴  Mohammad Taghi Shakeri¹  Shima Tavallaie¹  Majid Ghayour-Mobarhan¹  Hasan Boskabadi²  Shabnam Mohammadi³  Mina Mousavi¹  Gholamali Maamouri² 

[1] Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran;Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran;Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran;Department of Nutrition and Metabolism, University of Surrey, Guilford, UK;Gynecology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran;Division of Medical Education, Brighton and Sussex Medical School, Brighton, UK

关键词: Vascular Endothelial Growth Factor Receptor-1;    Glutathione Peroxidase;    Plasminogen Activator Inhibitor-1 Deficiency;    Pre-Eclampsia;    Selenium;   

DOI  :  10.17795/semj21596

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Preeclampsiaisahypertensivedisorderofpregnancy,whichisassociatedwithincreasedmaternalandprenatalmorbidityandmortality.Oxidativestressassociatedwithpreeclampsiamaybeaconsequenceofreducedantioxidantdefensepathwaysthatmightinvolveinadequateglutathioneperoxidase(GPx)levels,perhapslinkedtoreducedseleniumavailability.ThesolubleFMS-liketyrosinekinase-1(sFlt-1)thatcontributestoendothelialdysfunctionmaybepartiallyresponsiblefortheclinicalmanifestationofpreeclampsia.Furthermore,elevatedplasminogenactivatorinhibitor-1(PAI-1)anddecreasedplasminogenactivatorinhibitor-2(PAI-2)arefoundinpreeclampticwomen.Hence,thePAI1:PAI2ratiomaybeapredictorofpreeclampsia.Objectives:TheobjectiveofthisstudywastoevaluatetheeffectsofseleniumsupplementationonsFlt-1,GPxactivityandPAI1:PAI2ratioinpregnantwomen.MaterialsandMethods:Atotalof125high-riskpregnantwomen(withafamilialhistoryofhypertension,hyperlipidemiaandotherriskfactorsforpreeclampsia)inthefirsttrimestersofpregnancywereassignedtoeitherselenium(n=61)orplacebo(n=64)groups.Theseleniumgroupreceived100μg/dayofseleniumasaselenium-yeasttabletforsixmonths.Theplacebogroupreceivedaplaceboyeasttabletforthesameperiod.Atthebeginningofthetrialandattheend,bloodsampleswerecollectedandthelevelsofsFlt-1,PAI-1,PAI2andGPxweremeasuredinbloodserumandplasma.Results:Serumseleniumconcentrationswereraisedintheseleniumgroup(Plt;0.001)fromthefirsttothethirdtrimester,butwasunchangedintheplacebogroup(P=0.85).TheresultsshowedthatsFlt-1hadsignificantlyincreasedinbothgroupsbytheendofthegestationperiod,andseleniumsupplementationhadnosignificanteffectontheseleniumgroup(P=0.51).However,GPxactivitywassignificantlyincreasedintheseleniumtreatmentgroupaftersupplementationcomparedtothecontrolgroup(Plt;0.001).ThePAI1:PAI2ratiowasnotsignificantlydifferentbetweenthetwogroups(P=0.44).Conclusions:SeleniumintakeduringthesecondandthirdtrimesterofpregnancyincreasedGPxactivitybutdidnothaveasignificanteffectonserumsFlt-1levelsortheratioofPAI1:PAI2intheserum.

【 授权许可】

Unknown