Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level

BMC Microbiology

Yingtao Li¹  Qing Li¹  Fang Chen¹  Wenzhi He¹  Kejian Wang¹  Yu Gan¹  Weizhen Wu¹ 

[1] Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;

关键词: Gestational diabetes mellitus;    Gut microbiota;    Bacterial species;    16S rRNA microarray;   

DOI  :  10.1186/s12866-021-02207-0

来源: Springer

【 摘 要 】

BackgroundGestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM.MethodsAn analysis based on 16S rRNA microarray was performed on fecal samples obtained from 30 women with GDM and 28 healthy pregnant women.ResultsWe found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose.ConclusionsThis study suggests that there are large amounts of differentially abundant taxa between GDM and control group at the genus and the species level. Some of these taxa were correlated with blood glucose level and might be used as biomarkers for diagnoses and therapeutic targets for probiotics or synbiotics.

【 授权许可】

CC BY