Evaluation of risk factors for cerebral palsy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Hend Magdy¹  Dina Salama Abd Elmagid² 

[1] Department of Public Health & Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt;Neurology Unit, Pediatrics Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;

关键词: Cerebral palsy;    Central nervous system;    Risk factors;    Motor impairments;   

DOI  :  10.1186/s41983-020-00265-1

来源: Springer

【 摘 要 】

BackgroundCerebral palsy (CP) has been identified as one of the most important and common causes of childhood disabilities worldwide and is often accompanied by multiple comorbidities. CP is defined as a group of disorders of the development of movement and posture, causing activity limitation that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The objective of our study was to describe main clinical pattern and motor impairments of our patients, and to evaluate the presence of risk factors and if there is a relation to the type of cerebral palsy.MethodsChildren with cerebral palsy were retrospectively enrolled over 2 years from the neurology outpatient clinics. Cerebral palsy risk factors and motor impairments were determined through caregiver interviews, review of medical records, and direct physical examination.ResultsOne thousand children with cerebral palsy were enrolled. Subjects were 64.4% male, with a median age of 2.5 years. The risk factors for cerebral palsy in our study were antenatal (21%), natal and post-natal (30.5%), post-neonatal (17.1%), and unidentified (31.4%). Antenatal as CNS malformation (26.6%), maternal DM (17.6%), prolonged rupture of membrane (11.9%), maternal hemorrhage (10.4%), and pre-eclampsia (4.7%). Natal and post-natal as hypoxic ischemic encephalopathy (28.5%), infection (16.3%), hyperbilirubinemia (12.7%), cerebrovascular accidents (8.8%), meconium aspiration (6.2%), and intracranial hemorrhage. Post-neonatal as CNS infection (34.5%), cerebrovascular accidents (28.6%), sepsis (23.9%), and intracranial hemorrhage (8.7%).ConclusionsCerebral palsy has different etiologies and risk factors. Further studies are necessary to determine optimal preventative strategies in these patients.

【 授权许可】

CC BY