CardiOvaScular Mechanisms In Covid-19: methodology of a prospective observational multimodality imaging study (COSMIC-19 study)

BMC Cardiovascular Disorders

Khalid Makhdomi¹  Kevin O. Ombati¹  Edward Nganga¹  Sudhir Vinayak¹  Samuel Gitau¹  Michael H. Chung²  Anoop S. V. Shah³  Shirjel R. Alam⁴ 

[1] Aga Khan University Hospital, Nairobi, Kenya;Emory University, Atlanta, USA;London School of Hygiene and Tropical Medicine, London, UK;Manchester University, Manchester, UK;

关键词: COVID-19;    CMR;    FDG;    18F-FDG-PET/CT;    CTCA;    Cardiovascular;    Troponin;    Cardiac injury;    Imaging;   

DOI  :  10.1186/s12872-021-02027-0

来源: Springer

【 摘 要 】

Background8–28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim to use multimodality cardiac imaging including cardiac magnetic resonance (CMR) imaging, computed tomography coronary angiography (CTCA) and positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-d-glucose integrated with computed tomography (18F-FDG-PET/CT) to identify the cardiac pathophysiological mechanisms related to COVID-19 infections.MethodsThis is a single-centre exploratory observational study aiming to recruit 50 patients with COVID-19 infection who will undergo cardiac biomarker sampling. Of these, 30 patients will undergo combined CTCA and 18F-FDG-PET/CT, followed by CMR. Prevalence of obstructive and non-obstructive atherosclerotic coronary disease will be assessed using CTCA. CMR will be used to identify and characterise myocardial disease including presence of cardiac dysfunction, myocardial fibrosis, myocardial oedema and myocardial infarction. 18F-FDG-PET/CT will identify vascular and cardiac inflammation. Primary endpoint will be the presence of cardiovascular pathology and the association with troponin levels.DiscussionThe results of the study will identify the presence and modality of cardiac injury associated COVID-19 infection, and the utility of multi-modality imaging in diagnosing such injury. This will further inform clinical decision making during the pandemic.Trial Registration: This study has been retrospectively registered at the ISRCTN registry (ID ISRCTN12154994) on 14th August 2020. Accessible at https://www.isrctn.com/ISRCTN12154994

【 授权许可】

CC BY