Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Cell & Bioscience

Wu-Jun Wang¹  Yun-Xuan Jia²  Tao-Yue Yang³  Yi Miao³  Kui-Rong Jiang³  Peng-Fei Wu³  Wan-Li Ge³  Jing-Jing Zhang³  Ling-Dong Meng³  Qun Chen³  Hao Yuan³  Xu-Min Huang³  Peng Shen³ 

[1] Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China;Nanjing Medical University, Nanjing, China;Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People’s Republic of China;Nanjing Medical University, Nanjing, China;

关键词: YY1;    Pancreatic neuroendocrine tumor;    Pancreatic ductal adenocarcinoma;    Mutation;    Tumor suppressor;   

DOI  :  10.1186/s13578-021-00602-8

来源: Springer

【 摘 要 】

Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), have lost the opportunity to receive for the best treatment at the time of diagnosis. Although chemotherapy and radiotherapy have shown good therapeutic results in other tumors, their therapeutic effects on pancreatic tumors are minimal. A multifunctional transcription factor, Yin-Yang 1 (YY1) regulates the transcription of a variety of important genes and plays a significant role in diverse tumors. Studies have shown that targeting YY1 can improve the survival time of patients with tumors. In this review, we focused on the mechanism by which YY1 affects the occurrence and development of pancreatic tumors. We found that a YY1 mutation is specific for insulinomas and has a role in driving the degree of malignancy. In addition, changes in the circadian network are a key causative factor of PDAC. YY1 promotes pancreatic clock progression and induces malignant changes, but YY1 seems to act as a tumor suppressor in PDAC and affects many biological behaviors, such as proliferation, migration, apoptosis and metastasis. Our review summarizes the progress in understanding the role of YY1 in pancreatic endocrine and exocrine tumors and provides a reasonable assessment of the potential for therapeutic targeting of YY1 in pancreatic tumors.

【 授权许可】

CC BY