Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

Diagnostic Pathology

Iancu Emil Plesea²  Mirela Ghilusi²  Sandu Ramboiu¹  Valeriu Surlin¹ 

[1] Department of Surgery, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200393, Craiova, Romania;Department of Pathology, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200349, Craiova, Romania

关键词: Splenopancreatectomy;    Chronic pancreatitis;    Pancreatic neuroendocrine tumor;   

Others  :  807949
DOI  :  10.1186/1746-1596-7-132

 received in 2012-02-10, accepted in 2012-09-19,  发布年份 2012

【 摘 要 】

Pancreatic neuroendocrine tumors are a rare entity with an incidence between 2 per million to 5 per 100 000. Association with pancreatitis (acute or chronic) is rare and is considered to be determined by the tumoral obstruction of pancreatic ducts, but sometimes occurs without any apparent relationship between them. Non-functional neuroendocrine pancreatic tumors are usually diagnosed when either very large or metastatic. Small ones are occasionally diagnosed when imagery is performed for other diagnostic reasons. Intraoperative discovery is even rarer and poses problems of differential diagnosis with other pancreatic tumors. Association with chronic pancreatitis is rare and usually due to pancreatic duct obstruction by the tumor. We describe the case of a patient with a small non-functioning neuroendocrine tumor in the pancreatic tail accidentally discovered during surgery for delayed traumatic splenic rupture associated with chronic alcoholic pancreatitis. The tumor of 1.5cm size was well differentiated and confined to the pancreas, and was resected by a distal splenopancreatectomy.

Conclusions

Surgeons should be well aware of the rare possibility of a non-functional neuroendocrine tumor in the pancreas, associated with chronic pancreatitis, surgical resection being the optimal treatment for cure. Histopathology is of utmost importance to establish the correct diagnosis, grade of differentiation, malignancy and prognosis.

Virtual slides

The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/2114470176676003 webcite.

【 授权许可】

   
2012 Surlin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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