Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

Journal of Translational Medicine

Xiuying Wang¹  Bowen Xin¹  David Feng¹  Michael Fulham²  Jiangnan He³  Jianfeng Zhu³  Ying Fan⁴  Xun Xu⁴  Qiuying Chen⁴  Haidong Zou⁴  Dazhen Sun⁵  Lisheng Wang⁵  Yuchen Du⁶ 

[1] Biomedical and Multimedia Information Technology Research Group, School of Computer Science, The University of Sydney, 2006, Sydney, NSW, Australia;Department of Molecular Imaging, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia;Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, 200040, Shanghai, China;Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, 200040, Shanghai, China;Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai General Hospital, SJTU School of Medicine, Shanghai, China;National Clinical Research Center for Eye Diseases, 20080, Shanghai, China;The Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University (SJTU), 800 Dongchuan RD. Minhang District, 200240, Shanghai, People’s Republic of China;The Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University (SJTU), 800 Dongchuan RD. Minhang District, 200240, Shanghai, People’s Republic of China;Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, 200040, Shanghai, China;Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai General Hospital, SJTU School of Medicine, Shanghai, China;National Clinical Research Center for Eye Diseases, 20080, Shanghai, China;

关键词: Pathologic myopia;    Myopic maculopathy;    Feature mining;    Machine learning;    Radiomics;   

DOI  :  10.1186/s12967-021-02818-1

来源: Springer

【 摘 要 】

BackgroundMyopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to MM. To explore additional features strongly related with MM from optic disc region, we employ a machine learning based radiomics analysis method, which could explore and quantify more hidden or imperceptible MM-related features to the naked eyes and contribute to a more comprehensive understanding of MM and therefore may assist to distinguish the high-risk population in an early stage.MethodsA total of 457 eyes (313 patients) were enrolled and were divided into severe MM group and without severe MM group. Radiomics analysis was applied to depict features significantly correlated with severe MM from optic disc region. Receiver Operating Characteristic were used to evaluate these features’ performance of classifying severe MM.ResultsEight new MM-related image features were discovered from the optic disc region, which described the shapes, textural patterns and intensity distributions of optic disc region. Compared with clinically reported MM-related features, these newly discovered features exhibited better abilities on severe MM classification. And the mean values of most features were markedly changed between patients with peripapillary diffuse chorioretinal atrophy (PDCA) and macular diffuse chorioretinal atrophy (MDCA).ConclusionsMachine learning and radiomics method are useful tools for mining more MM-related features from the optic disc region, by which complex or even hidden MM-related features can be discovered and decoded. In this paper, eight new MM-related image features were found, which would be useful for further quantitative study of MM-progression. As a nontrivial byproduct, marked changes between PDCA and MDCA was discovered by both new image features and clinic features.

【 授权许可】

CC BY