Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Reproductive Biology and Endocrinology

Ravit Nahum¹  Aliza Segev-Zahav¹  Jigal Haas¹  Meirav Noach-Hirsh¹  Adva Aizer¹  Raoul Orvieto² 

[1] Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel;

关键词: COVID-19;    vaccination;    Ovarian stimulation;    embryo quality;    IVF;   

DOI  :  10.1186/s12958-021-00757-6

来源: Springer

【 摘 要 】

ObjectiveNo information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.DesignAn observational study.SettingA tertiary, university-affiliated medical center.Patients and MethodsAll couples undergoing consecutive ovarian stimulation cycles for IVF before and after receiving mRNA SARS-CoV-2 vaccine, and reached the ovum pick-up (OPU) stage. The stimulation characteristics and embryological variables of couples undergoing IVF treatments after receiving mRNA SARS-CoV-2 vaccine were assessed and compared to their IVF cycles prior to vaccination.Main outcome measuresStimulation characteristics and embryological variables.ResultsThirty-six couples resumed IVF treatment 7–85 days after receiving mRNA SARS-CoV-2 vaccine. No in-between cycles differences were observed in ovarian stimulation and embryological variables before and after receiving mRNA SARS-CoV-2 vaccination.ConclusionsmRNA SARS-CoV-2 vaccine did not affect patients’ performance or ovarian reserve in their immediate subsequent IVF cycle. Future larger studies with longer follow-up will be needed to validate our observations.

【 授权许可】

CC BY