Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver disease in 2 decades: the NAGALA study

BMC Gastroenterology

Takuro Okamura¹  Michiaki Fukui¹  Yoshitaka Hashimoto¹  Masahide Hamaguchi¹  Akihiro Obora²  Takao Kojima² 

[1] Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan;Department of Gastroenterology, Asahi University Hospital, Gifu, Japan;

关键词: Cohort;    Non-alcoholic fatty liver disease;    NAFLD;    Epidemiology;    Trend;   

DOI  :  10.1186/s12876-021-01809-2

来源: Springer

【 摘 要 】

BackgroundIn this study, to clarify the evolving background of people with non-alcoholic fatty liver disease (NAFLD), we compared the current prevalence of NAFLD with that of 2 decades ago.MethodsWe included two cohorts. The past cohort was from 1994 to 1997 and included 4279 men and 2502 women. The current cohort was from 2014 to 2017 and included 8918 men and 7361 women. NAFLD was diagnosed by abdominal ultrasonography.ResultsThe prevalence of NAFLD increased in both genders throughout these 2 decades (18.5% in the past cohort and 27.1% in the current cohort for men; and 8.0% in the past cohort and 9.4% in the current cohort for women). The prevalence of hyperglycemia increased, whereas the prevalence of low high-density lipoprotein cholesterol levels and hypertriglyceridemia significantly decreased. There was no significant difference in the mean body mass index. Multivariate analysis revealed that the prevalence of obesity and body mass index were significantly associated with the prevalence of NAFLD in both the past and current cohorts.ConclusionsThe incidence of NAFLD significantly increased throughout these 2 decades, and obesity is the most prevalent factor. Thus, body weight management is an essential treatment option for NAFLD.

【 授权许可】

CC BY