Types of nuclear localization signals and mechanisms of protein import into the nucleus

Cell Communication and Signaling

Jianjun Qiao¹  Tao Wu²  Biao Zhang²  Suke Liu²  Haihua Ruan²  Juane Lu²  Wenjun Song² 

[1] Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China;Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China;SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China;Tianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China;

关键词: Nuclear localization signal;    Nuclear pore complex;    Importin;   

DOI  :  10.1186/s12964-021-00741-y

来源: Springer

【 摘 要 】

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus.9b35b5XrF5YBVYeQB6JADFVideo Abstract

【 授权许可】

CC BY