LINC00261: a burgeoning long noncoding RNA related to cancer

Cancer Cell International

Xiao Yu¹  Menggang Zhang¹  Qiyao Zhang¹  Wenzhi Guo¹  Yuting He¹  Zongzong Sun²  Fang Gao³ 

[1] Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshedong Road, Erqi District, 450052, Zhengzhou, China;Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China;Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ, Transplantation at Henan Universities, 450052, Zhengzhou, China;Henan Key Laboratory of Digestive Organ Transplantation, 450052, Zhengzhou, China;Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China;Health Management Center, Binzhou People’s Hospital, 256600, Binzhou, China;

关键词: Long noncoding RNA 261;    Biomarker;    Human cancers;    Biological function;    Therapeutic target;   

DOI  :  10.1186/s12935-021-01988-8

来源: Springer

【 摘 要 】

Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long intergenic non-protein coding RNA 261 (LINC00261), a recently discovered lncRNA, is abnormally expressed in a variety of human malignancies, including pancreatic cancer, gastric cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, breast cancer, laryngeal carcinoma, endometrial carcinoma, esophageal cancer, prostate cancer, choriocarcinoma, and cholangiocarcinoma. LINC00261 mainly functions as a tumor suppressor that regulates a variety of biological processes in the above-mentioned cancers, such as cell proliferation, apoptosis, motility, chemoresistance, and tumorigenesis. In addition, the up-regulation of LINC00261 is closely correlated with both favorable prognoses and many clinical characteristics. In the present review, we summarize recent research documenting the expression and biological mechanisms of LINC00261 in tumor development. These findings suggest that LINC00261, as a tumor suppressor, has bright prospects both as a biomarker and a therapeutic target.

【 授权许可】

CC BY