The intersection of COVID-19 and cancer: signaling pathways and treatment implications

Molecular Cancer

Yujun Wei¹  Fangfang Zhou²  Zhi Zong³  Long Zhang⁴  Jiang Ren⁵ 

[1] Anhui Anlong Gene Technology Co., Ltd, 230041, Hefei, China;Institutes of Biology and Medical Sciences, Soochow University, 215123, Suzhou, China;Institutes of Biology and Medical Sciences, Soochow University, 215123, Suzhou, China;MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, 310058, Hangzhou, China;The Eighth Affiliated Hospital, Sun Yat-sen University, 518033, Shenzhen, China;MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, 310058, Hangzhou, China;The Eighth Affiliated Hospital, Sun Yat-sen University, 518033, Shenzhen, China;

关键词: COVID-19;    Cancer;    Signaling pathway;    Treatment implications;   

DOI  :  10.1186/s12943-021-01363-1

来源: Springer

【 摘 要 】

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health concern. Patients with cancer have been disproportionately affected by this pandemic. Increasing evidence has documented that patients with malignancies are highly susceptible to severe infections and mortality from COVID-19. Recent studies have also elucidated the molecular relationship between the two diseases, which may not only help optimize cancer care during the pandemic but also expand the treatment for COVID-19. In this review, we highlight the clinical and molecular similarities between cancer and COVID-19 and summarize the four major signaling pathways at the intersection of COVID-19 and cancer, namely, cytokine, type I interferon (IFN-I), androgen receptor (AR), and immune checkpoint signaling. In addition, we discuss the advantages and disadvantages of repurposing anticancer treatment for the treatment of COVID-19.

【 授权许可】

CC BY