Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia

BMC Infectious Diseases

Nur Izzati Supian¹  Yutaka Takebe²  Kok Keng Tee³  Jack Bee Chook⁴  Kim Tien Ng⁵  Kok Gan Chan⁶ 

[1] Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan;Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Selangor Darul Ehsan, Malaysia;Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Selangor Darul Ehsan, Malaysia;Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;Infectious Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore;Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia;International Genome Centre, Jiangsu University, Zhenjiang, China;

关键词: Enterovirus;    Coxsackievirus;    Acute respiratory tract infections;    Outbreak;   

DOI  :  10.1186/s12879-021-06148-x

来源: Springer

【 摘 要 】

BackgroundCoxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans.MethodsA molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia.ResultsEpidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time.ConclusionsThe study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks.

【 授权许可】

CC BY