Epidemiology of respiratory viral infections in people with acute respiratory tract infections in Africa: the VARIAFRICA systematic review and meta-analysis protocol

Systematic Reviews

Jean Joel Bigna¹  Sebastien Kenmoe²  Richard Njouom²  Fredy Brice N. Simo³  Abdou Fatawou Modiyinji⁴ 

[1] Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, P.O. Box 1274, 451 Rue 2005, Yaoundé, Cameroon;0000 0001 2171 2558, grid.5842.b, School of Public Health, Faculty of Medicine, University of Paris Sud,, 63 Rue Gabriel Péri, 94270, Le Kremlin-Bicêtre, France;Department of Virology, Centre Pasteur of Cameroon, P.O. Box 1274, 451 Rue 2005, Yaoundé, Cameroon;Department of Virology, Centre Pasteur of Cameroon, P.O. Box 1274, 451 Rue 2005, Yaoundé, Cameroon;0000 0001 2173 8504, grid.412661.6, Department of Biochemistry, Faculty of Sciences, University of Yaoundé 1, P.O. Box 337, Yaoundé, Cameroon;Department of Virology, Centre Pasteur of Cameroon, P.O. Box 1274, 451 Rue 2005, Yaoundé, Cameroon;0000 0001 2173 8504, grid.412661.6, Department of Biology and Animal Physiology, Faculty of Sciences, University of Yaoundé 1, P.O. Box 337, Yaoundé, Cameroon;

关键词: Epidemiology;    Respiratory viruses;    Acute respiratory tract infections;    Africa;   

DOI  :  10.1186/s13643-019-1037-1

来源: publisher

【 摘 要 】

IntroductionBetter characterisation of the epidemiological data on respiratory viral infections among people with acute respiratory tract infection (ARTI) can help to implement efficient strategies to curb the burden of ARTI in Africa. We will conduct a systematic review and meta-analysis to determine the prevalence and factors associated with respiratory viral infection in people of all ages with ARTI residing in Africa.MethodsThis work will include cross-sectional studies published between January 1, 2000 and December 31, 2017, without any language restriction, on populations residing in African countries. We will consider studies that reported the prevalence of respiratory viruses in people with ARTI confirmed by a polymerase chain reaction technique. We will be searching PubMed, Embase, African Journals Online, Web of Science, and Global Index Medicus. The selection of relevant studies, extraction of data, and evaluation of the quality of the articles will be carried out independently by two review authors, and the discrepancies will be resolved by consensus or intervention of a third author. The heterogeneity of the studies will be assessed using the χ2 test on Cochrane’s Q statistic. Publication bias will be assessed by the Egger test. Studies will be pooled using a random-effect meta-analysis model. Results will be presented by age group and sub-region of Africa. Using meta-regression models, we will identify factors associated with viral infections in people with ARTI.DiscussionThis systematic review and meta-analysis is based on published data and therefore does not require ethical approval. This work will serve as a basis for the development of strategies for prevention and control ARTI in Africa and will also serve to identify data gaps and guide future investigations. The final report will be published in peer-reviewed journals as a scientific article and presented in workshops, conferences, and scientific conferences.Systematic review registrationPROSPERO, CRD42018088261.

【 授权许可】

CC BY