Adherence to quarterly HIV prevention services and its impact on HIV incidence in men who have sex with men in West Africa (CohMSM ANRS 12324 – Expertise France)

BMC Public Health

Bintou Dembélé Keita¹  Kader Maiga¹  Alou Coulibaly¹  Fodié Diallo¹  Issa Traoré²  Ter Tiero Elias Dah³  Daniela Rojas-Castro⁴  Paméla Palvadeau⁴  Malan Jean-Baptiste Kouamé⁵  Camille Anoma⁵  Mawuényégan Kouamivi Agboyibor⁶  Ephrem Mensah⁶  Marion Mora⁷  Bruno Spire⁷  Luis Sagaon-Teyssier⁷  Issifou Yaya⁸  Christian Laurent⁸ 

[1] ARCAD-SIDA, Bamako, Mali;Association African Solidarité, Ouagadougou, Burkina Faso;Association African Solidarité, Ouagadougou, Burkina Faso;TransVIHMI, Univ Montpellier, Inserm, IRD, Montpellier, France;Institut National de Santé Publique, Centre Muraz, Bobo-Dioulasso, Burkina Faso;Coalition Internationale Sida, Pantin, France;Espace Confiance, Abidjan, Côte d’Ivoire;Espoir Vie Togo, Lomé, Togo;SESSTIM, Aix Marseille Univ, Inserm, IRD, Marseille, France;TransVIHMI, Univ Montpellier, Inserm, IRD, Montpellier, France;

关键词: HIV;    Prevention;    Incidence;    MSM;    Africa;   

DOI  :  10.1186/s12889-021-10994-4

来源: Springer

【 摘 要 】

BackgroundAccess to tailored HIV prevention services remains limited for West African MSM. We assessed adherence to quarterly HIV prevention services and its impact on HIV incidence in MSM followed up in four cities in Burkina Faso, Côte d’Ivoire, Mali, and Togo.MethodsWe performed a prospective cohort study between 2015 and 2018. HIV-negative MSM aged over 18 benefited from quarterly medical visits which included a clinical examination, HIV testing, screening and treatment for other sexually transmitted infections, peer-led counselling and support, and the provision of condoms and lubricants. Determinants of adherence to quarterly follow-up visits and incident HIV infections were identified using generalized estimating equation models and Cox proportional hazard models, respectively.Results618 MSM were followed up for a median time of 20.0 months (interquartile range 15.2–26.3). Overall adherence to quarterly follow-up visits was 76.5% (95% confidence interval [CI] 75.1–77.8), ranging from 66.8% in Abidjan to 87.3% in Lomé (p < 0.001). 78 incident HIV infections occurred during a total follow-up time of 780.8 person-years, giving an overall incidence of 10.0 per 100 person-years (95% CI 8.0–12.5). Adherence to quarterly follow-up visits was not associated with the risk of incident HIV infection (adjusted hazard ratio 0.80, 95% CI 0.44–1.44, p = 0.545).ConclusionsStrengthening HIV prevention services among MSM in West Africa, including the use of PrEP, will be critical for controlling the epidemic, not only in this key population but also in the general population. Quarterly follow-up of MSM, which is essential for PrEP delivery, appears feasible.Trial registrationClinicalTrials.gov, number NCT02626286 (December 10, 2015).

【 授权许可】

CC BY