Construction of nanomaterials as contrast agents or probes for glioma imaging

Journal of Nanobiotechnology

Jingchao Li¹  Yu Luo²  Shaojun Peng³  Wei Zhao³  Ligong Lu³  Xiangrong Yu³ 

[1] College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 201620, Shanghai, China;School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, China;Zhuhai Precision Medical Center, Zhuhai Interventional Medical Center, Zhuhai People’s Hospital (Affiliated With Jinan University), 519000, Zhuhai, Guangdong, China;

关键词: Glioma imaging;    Nanomaterials;    Blood–brain-barrier;    Contrast agents;    Probes;    Biomedical imaging;   

DOI  :  10.1186/s12951-021-00866-9

来源: Springer

【 摘 要 】

Malignant glioma remains incurable largely due to the aggressive and infiltrative nature, as well as the existence of blood–brain-barrier (BBB). Precise diagnosis of glioma, which aims to accurately delineate the tumor boundary for guiding surgical resection and provide reliable feedback of the therapeutic outcomes, is the critical step for successful treatment. Numerous imaging modalities have been developed for the efficient diagnosis of tumors from structural or functional aspects. However, the presence of BBB largely hampers the entrance of contrast agents (Cas) or probes into the brain, rendering the imaging performance highly compromised. The development of nanomaterials provides promising strategies for constructing nano-sized Cas or probes for accurate imaging of glioma owing to the BBB crossing ability and other unique advantages of nanomaterials, such as high loading capacity and stimuli-responsive properties. In this review, the recent progress of nanomaterials applied in single modal imaging modality and multimodal imaging for a comprehensive diagnosis is thoroughly summarized. Finally, the prospects and challenges are offered with the hope for its better development.

【 授权许可】

CC BY