Epidemiological and clinical characteristics of imported cases of COVID-19: a multicenter study

BMC Infectious Diseases

Sijia Tian¹  Ying Zhang²  Jinjun Guo²  Yi Xu²  Yu Ma²  Yuguo Chen³  Jialiang Liu⁴  Shaoping Wang⁴  Kai Liao⁵  Shixiong Yang⁵  Jinjun Zhang⁶  Xinyan Qin⁷ 

[1] Beijing Emergency Medical Center, 100031, Beijing, China;Chongqing University Central Hospital, Chongqing Emergency Medical Center, 630014, Chongqing, China;Emergency Department, Qilu Hospital, Shandong University, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, 250012, Jinan, Shandong, China;Jinan Emergency Medical Center, 250021, Jinan, Shandong, China;Nanning Emergency Medical Center, 530022, Nanning, Guangxi, China;School of Medicine, Shandong University, 250012, Jinan, Shandong, China;Beijing Emergency Medical Center, 100031, Beijing, China;Uninted Family Healthcare, 100015, Beijing, China;

关键词: COVID-19;    Epidemiological characteristics;    Clinical feature;    imported case;   

DOI  :  10.1186/s12879-021-06096-6

来源: Springer

【 摘 要 】

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic continues to expand. Herein, we report the epidemiological and clinical features of 478 patients with confirmed COVID-19 from a multicenter study conducted in four cities in China excluding Wuhan.MethodsA total of 478 patients transferred by emergency medical services to designated hospitals in four major cities in China (Beijing, Chongqing, Jinan, and Nanning) were enrolled. We compared the characteristics of imported and indigenous cases and calculated the frequencies of fatal, severe, mild, and asymptomatic disease. The results were used to generate a pyramid of COVID-19 severity.ResultsThe mean age of patients with COVID-19 was 46.9 years and 49.8% were male. The most common symptoms at onset were fever (69.7%), cough (47.5%), fatigue (24.5%), dyspnea (8.4%), and headache (7.9%). Most cases (313, 65.5%) were indigenous, while 165 (34.5%) were imported. Imported cases dominated during the early stages of the pandemic, but decreased from 1 February 2020 as indigenous cases rose sharply. Compared with indigenous cases, imported cases differed significantly in terms of sex (P = 0.002), severity of disease (P = 0.006), occurrence of fever (P < 0.001), family clustering (P < 0.001), history of contact (P < 0.001), and primary outcome (P < 0.001).ConclusionsWithin the population studied, imported cases had distinct characteristics from those of indigenous cases, with lower fatality rates and higher discharge rates. New infections shifted from imported cases to local infection gradually, and overall infections have declined to a low level. We suggest that preventing import of cases and controlling spread within local areas can help prevent SARS-CoV-2 infection spread.

【 授权许可】

CC BY