Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

Nanoscale Research Letters

Wen Wang¹  Guangfei Yang¹  Liyuan Ma¹  Yating Wu¹  Ruijiao Chang¹  Chengrong Mi¹  Chenyu Wang²  Qian Zhang²  Hongyuan Shen²  Hongyu Tao²  Hanfei Zhang²  Jiaojiao Qi²  Jiaxing Wang²  Furong Zhang² 

[1] Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, China;Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, China;School of Clinical Medicine, Ningxia Medical University, Yinchuan, China;

关键词: Nanoparticle;    Sonodynamic therapy;    Contrast-enhanced ultrasound;    Anti-metastasis;    LIFU;   

DOI  :  10.1186/s11671-021-03532-z

来源: Springer

【 摘 要 】

The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core–shell structure. The synergistic Ce6/PFP/DTX/PLGA nanoparticles (CPDP NPs) featured with excellent biocompatibility and stability primarily enable its further application. Upon low-intensity focused ultrasound (LIFU) irradiation, the enhanced ultrasound imaging could be revealed both in vitro and in vivo. More importantly, combined with LIFU, the nanoparticles exhibit intriguing antitumor capability through Ce6-induced cytotoxic reactive oxygen species as well as DTX releasing to generate a concerted therapeutic efficiency. Furthermore, this treating strategy actives a strong anti-metastasis capability by which lung metastatic nodules have been significantly reduced. The results indicate that the SDT-oriented nanoplatform combined with chemotherapy could be provided as a promising approach in elevating effective synergistic therapy and suppressing lung metastasis of breast cancer.

【 授权许可】

CC BY