Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Cancer Cell International

Tahereh Farkhondeh¹  Mohsen Talebi²  Marjan Talebi³  Jurga Bernatoniene⁴  Dalia M. Kopustinskiene⁴  Saeed Samarghandian⁵  Jesus Simal-Gandara⁶ 

[1] Cardiovscular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran;Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran;Department of Chemistry and Biochemistry, University of Texas at Arlington, 76019, Arlington, TX, USA;Food Safety Net Services (FSNS), 78216, San Antonio, TX, USA;Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 1991953381, Tehran, Iran;Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, 50161, Kaunas, Lithuania;Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran;Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense Campus, 32004, Ourense, Spain;

关键词: Chrysin;    Flavonoids;    Oxidative stress;    Inflammation;    Apoptosis;    Metastasis;    Proliferation;    Transcription factors;    Cancer;   

DOI  :  10.1186/s12935-021-01906-y

来源: Springer

【 摘 要 】

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies.Graphic abstract

【 授权许可】

CC BY