The microbiome’s relationship with congenital heart disease: more than a gut feeling

Journal of Congenital Cardiology

Merry L. Lindsey¹  Dan Feng²  Jason T. Christensen²  Jeffrey D. Salomon³  Anji T. Yetman⁴  Amar B. Singh⁵ 

[1] Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, USA;Research Service, Nebraska-Western Iowa Health Care System, Nebraska, Omaha, USA;Department of Pediatrics, University of Nebraska Medical Center, Omaha, USA;Department of Pediatrics, University of Nebraska Medical Center, Omaha, USA;Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, USA;Child Health Research Institute, University of Nebraska Medical Center, Omaha, USA;Department of Pediatrics, University of Nebraska Medical Center, Omaha, USA;Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA;Research Service, Nebraska-Western Iowa Health Care System, Nebraska, Omaha, USA;Department of Molecular Biology and Biochemistry, University of Nebraska Medical Center, Omaha, USA;

关键词: Congenital Heart Disease;    Microbiome;    Intestinal barrier dysfunction;    Systemic inflammation;    Cardiopulmonary bypass;   

DOI  :  10.1186/s40949-021-00060-4

来源: Springer

【 摘 要 】

Patients with congenital heart disease (CHD) are at risk for developing intestinal dysbiosis and intestinal epithelial barrier dysfunction due to abnormal gut perfusion or hypoxemia in the context of low cardiac output or cyanosis. Intestinal dysbiosis may contribute to systemic inflammation thereby worsening clinical outcomes in this patient population. Despite significant advances in the management and survival of patients with CHD, morbidity remains significant and questions have arisen as to the role of the microbiome in the inflammatory process. Intestinal dysbiosis and barrier dysfunction experienced in this patient population are increasingly implicated in critical illness. This review highlights possible CHD-microbiome interactions, illustrates underlying signaling mechanisms, and discusses future directions and therapeutic translation of the basic research.

【 授权许可】

CC BY