Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand’s university-based referral hospital

BMC Infectious Diseases

Wannee Kantakamalakul¹  Navin Horthongkham¹  Ranistha Ratanarat²  Rujipas Sirijatuphat³  Methee Chayakulkeeree³  Walaiporn Wangchinda³  Yong Rongrungruang³  Pornpan Koomanachai³  Susan Assanasen³  Pinyo Rattanaumpawan³  Nasikarn Angkasekwinai³  Anupop Jitmuang³  Yupin Suputtamongkol³  Nitipatana Chierakul⁴ 

[1] Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;

关键词: COVID-19;    Epidemiology;    Clinical characteristics;    Treatment;    Outcome;    Thailand;   

DOI  :  10.1186/s12879-021-06081-z

来源: Springer

【 摘 要 】

BackgroundThe epidemiology and outcomes of COVID-19 patients in Thailand are scarce.MethodsThis retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.ResultsThe prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.ConclusionsThe prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.

【 授权许可】

CC BY