NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer

Journal of Biomedical Science

Vladmir Cláudio Cordeiro de Lima¹  Victor Pianna de Andrade²  Susan Costantini³  Alfredo Budillon³  Mickaël Rialland⁴  Kelly Grace Magalhães⁵  Sara Socorro Faria⁵  Rebe Cedric⁶ 

[1] Department of Medical Oncology and Laboratory of Translational Immuno-Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil;Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil;Experimental Pharmacology Unit - Laboratory of Mercogliano (AV), Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, 80131, Naples, Italy;Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1231, 21000, Dijon, France;UFR Sciences de la Vie, Terre et Environnement, Université de Bourgogne Franche-Comté, 21000, Dijon, France;Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasilia, DF, Brazil;Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, 21000, Dijon, France;Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1231, 21000, Dijon, France;

关键词: Breast cancer;    Gasdermins;    IL-1β;    NLRP3 inflammasome;   

DOI  :  10.1186/s12929-021-00724-8

来源: Springer

【 摘 要 】

Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential and therapeutic outcome by altering the tumor immune microenvironment. These processes are mediated by a variety of cytokines, chemokines and growth factors that exert their biological functions either locally or distantly. Inflammasomes are protein signaling complexes that form in response to damage- and pathogen-associated molecular patterns (DAMPS and PAMPS), triggering the release of pro-inflammatory cytokines. The dysregulation of inflammasome activation can lead to the development of inflammatory diseases, neurodegeneration, and cancer. A crucial signaling pathway leading to acute and chronic inflammation occurs through the activation of NLRP3 inflammasome followed by caspase 1-dependent release of IL-1β and IL-18 pro-inflammatory cytokines, as well as, by gasdermin D-mediated pyroptotic cell death. In this review we focus on the role of NLRP3 inflammasome and its components in breast cancer signaling, highlighting that a more detailed understanding of the clinical relevance of these pathways could significantly contribute to the development of novel therapeutic strategies for breast cancer.

【 授权许可】

CC BY