Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report

Journal of Medical Case Reports

Yosuke Kawai¹  Yasuo Hirose¹  Naoko Mizouchi¹  Miyoshi Deguchi¹  Satoru Yoshida¹  Ken Kumagai¹ 

[1] Niigata City General Hospital Emergency & Critical Care Medicine, 463-7 Shumoku, Chuo-ku, 950-1197, Niigata, Japan;

关键词: Cold agglutinin disease;    Hemolytic anemia;    Fluid resuscitation;    Diabetic ketoacidosis;    Intensive care;   

DOI  :  10.1186/s13256-021-02784-8

来源: Springer

【 摘 要 】

BackgroundCold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the absence of exposure to cold.Case presentationA 71-year-old Japanese man was admitted to the emergency department with signs of hypotension and disturbed consciousness. He was diagnosed with diabetic ketoacidosis, and treatment with fluid resuscitation and insulin infusion was initiated. Laboratory test results obtained the following day indicated hemolytic anemia. On day 5 after admission, red blood cell agglutination was detected, and the patient was diagnosed with cold agglutinin disease.ConclusionsCold agglutinin disease should be considered in the differential diagnosis of progressive hemolytic anemia during fluid resuscitation, even if the solution is at room temperature.

【 授权许可】

CC BY