A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT

Journal of Otolaryngology - Head and Neck Surgery

Calvin Thompson¹  Dimitrios Scarvelis²  Laurie McLean³  Scott Kohlert⁴ 

[1] Canada. Hyperbaric Medicine Unit The Ottawa Hospital;Department of Medicine, University of Ottawa;Department of Otolaryngology – Head and Neck Surgery The Ottawa Hospital, University of Ottawa;ENT Associates of East Texas;

关键词: Nasal ischemia;    Acrocyanosis;    Cold agglutinin disease;    Hyperbaric oxygen;   

DOI  :  10.1186/s40463-019-0369-0

来源: DOAJ

【 摘 要 】

Abstract Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication.

【 授权许可】

Unknown