Applicability of somatic monitoring instructions in clinical practice guidelines on antipsychotic drug use

BMC Psychiatry

Arne J. Risselada¹  Hans Mulder²  Jurriaan M. J. L. Brouwer³  Erien Olde Hengel⁴  Eric N. van Roon⁵ 

[1] Department of Clinical Pharmacy, Wilhelmina Hospital Assen, Mailbox: 30.001, 9400 RA, Assen, Drenthe, The Netherlands;Department of Clinical Pharmacy, Wilhelmina Hospital Assen, Mailbox: 30.001, 9400 RA, Assen, Drenthe, The Netherlands;GGZ Drenthe Mental Health Services Drenthe, Assen, Drenthe, The Netherlands;Department of Pharmacotherapy, -Epidemiology & -Economics, Pharmacy and Pharmaceutical Sciences, University of Groningen, Groningen, Groningen, The Netherlands;Department of Psychiatry, Interdisciplinary Centre for Psychopathology and Emotion Regulation, University of Groningen, University Medical Centre Groningen, Groningen, Groningen, The Netherlands;Department of Clinical Pharmacy, Wilhelmina Hospital Assen, Mailbox: 30.001, 9400 RA, Assen, Drenthe, The Netherlands;GGZ Drenthe Mental Health Services Drenthe, Assen, Drenthe, The Netherlands;Department of Psychiatry, Research School of Behavioural and Cognitive Neurosciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands;Department of Pharmacotherapy, -Epidemiology & -Economics, Pharmacy and Pharmaceutical Sciences, University of Groningen, Groningen, Groningen, The Netherlands;Department of Pharmacotherapy, -Epidemiology & -Economics, Pharmacy and Pharmaceutical Sciences, University of Groningen, Groningen, Groningen, The Netherlands;Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, Friesland, The Netherlands;

关键词: SIM;    Applicability;    Somatic;    Monitoring;    Antipsychotic;   

DOI  :  10.1186/s12888-021-03162-w

来源: Springer

【 摘 要 】

BackgroundClinical practice guidelines (CPGs) recommend the monitoring of somatic parameters in patients treated with antipsychotic drugs in order to detect adverse effects. The objective of this study was to assess, in adult and (frail) elderly populations, the consistency and applicability of the somatic monitoring instructions recommended by established CPGs prior to and during antipsychotic drug use.MethodsA search for national and international CPGs was performed by querying the electronic database PubMed and Google. Somatic monitoring instructions were assessed for adult and (frail) elderly populations separately. The applicability of somatic monitoring instructions was assessed using the Systematic Information for Monitoring (SIM) score. Somatic monitoring instructions were considered applicable when a minimum SIM score of 3 was reached.ResultsIn total, 16 CPGs were included, with a total of 231 somatic monitoring instructions (mean: 14; range: 0–47). Of the somatic monitoring instructions, 87% were considered applicable, although critical values and how to respond to aberrant values were only present in 28 and 52% of the available instructions respectively. Only 1 CPG presented an instruction specifically for (frail) elderly populations.ConclusionsWe emphasize the need for a guideline with somatic monitoring instructions based on the SIM definition for both adult and (frail) elderly populations using antipsychotic drugs. In addition, CPGs should state that clear agreements should be made regarding who is responsible for interventions and somatic monitoring prior to and during antipsychotic drug use.

【 授权许可】

CC BY